Research

Our own research focusses on the generation of patient-specific iPSCs and their applications in genome editing, cardiac differentiation, tissue engineering and disease modelling. By combining iPSC technology with CRISPR/Cas9 genome editing and further state-of-the-art approaches, we aim to deeply investigate the development, function and pathophysiology of cardiomyocytes on molecular, omics-based, functional as well as pharmacological level. The spanning goal of our research is the identification of novel pathophysiological mechanisms in cardiomyopathy/heart failure and the development of preventive and/or curative therapies.